RESEARCH PAPER
Factors associated with non-adherence to antiretroviral treatment among HIV-infected patients in a high-altitude hospital
1
Universidad Continental, Huancayo, Peru
2
Infectious Diseases Unit, Hospital Nacional Ramiro Prialé Prialé, Huancayo, Peru
3
Universidad Nacional del Centro del Perú, Huancayo, Peru
Submission date: 2023-12-27
Acceptance date: 2024-01-04
Online publication date: 2026-01-19
KEYWORDS
TOPICS
ABSTRACT
Background:
Antiretroviral therapy (ART) has been fundamental in the management of human immunodeficiency virus (HIV) infection; however, achieving adherence to this treatment is a significant challenge, especially in unique geographic areas and populations. This study aimed to analyze the prevalence and factors associated with non-adherence to ART among patients with HIV infection in a high-altitude hospital.
Material and methods:
A cross-sectional study was conducted with a total of 160 patients using questionnaire for evaluation of adherence to antiretroviral treatment in patients with HIV/AIDS (CEAT-HIV). Data processing was performed with Stata 15 program to determine the association between risk factors and non-adherence to ART, with prevalence ratio (PR) calculated by generalized linear model of family Poisson. Statistical significance was defined at a p-value of 0.05.
Results:
The prevalence of poor adherence was 54.87%. Socio-demographic factors included male sex (PR: 1.45; p = 0.039), no family support (PR: 1.45; p = 0.017), and alcohol consumption (PR: 1.41; p = 0.017). Clinical factors were not statistically significant in the multivariate analysis.
Conclusions:
Our study revealed a high proportion of non-adherence to ART. The risk factors associated with non-adherence to ART among patients with HIV/AIDS were male sex, not having family support, and consuming alcohol.
Antiretroviral therapy (ART) has been fundamental in the management of human immunodeficiency virus (HIV) infection; however, achieving adherence to this treatment is a significant challenge, especially in unique geographic areas and populations. This study aimed to analyze the prevalence and factors associated with non-adherence to ART among patients with HIV infection in a high-altitude hospital.
Material and methods:
A cross-sectional study was conducted with a total of 160 patients using questionnaire for evaluation of adherence to antiretroviral treatment in patients with HIV/AIDS (CEAT-HIV). Data processing was performed with Stata 15 program to determine the association between risk factors and non-adherence to ART, with prevalence ratio (PR) calculated by generalized linear model of family Poisson. Statistical significance was defined at a p-value of 0.05.
Results:
The prevalence of poor adherence was 54.87%. Socio-demographic factors included male sex (PR: 1.45; p = 0.039), no family support (PR: 1.45; p = 0.017), and alcohol consumption (PR: 1.41; p = 0.017). Clinical factors were not statistically significant in the multivariate analysis.
Conclusions:
Our study revealed a high proportion of non-adherence to ART. The risk factors associated with non-adherence to ART among patients with HIV/AIDS were male sex, not having family support, and consuming alcohol.
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