REVIEW PAPER
Evidence of vitamin D deficiency in mediating disease progression among people living
with human immunodeficiency virus: a narrative review
1
Institute of Tourism and Hotel Management, Far Eastern University, Manila, Philippines
2
Institute of Human Nutrition and Food, University of the Philippines Los Baños, Laguna, Philippines
Submission date: 2022-05-31
Final revision date: 2022-08-24
Acceptance date: 2022-09-01
Online publication date: 2025-05-05
HIV & AIDS Review 2025;24(2):85-93
KEYWORDS
TOPICS
ABSTRACT
Advances in human immunodeficiency virus (HIV) diagnosis and management have increased life expectancy of HIV-infected individuals. However, despite rising quality of life among HIV patients, maintaining nutritional health and depending on antiretroviral regimen are key factors in the management of disease progression. Scientific articles published between January 2011 and December 2021 were examined. The study and compounding evidence from the literature revealed that poor nutrition and delayed adherence to HIV antiretroviral treatment contribute to micro-nutrient deficiency and HIV pathogenesis. Prevalence of micro-nutrient deficiencies were highly evidenced among HIV patients, particularly in countries with food insecurity and limited access to a variety of food. The use of antiretroviral drugs has the potential to lower vitamin D levels, consequently leading to disease progression by increasing oxidative stress, deterioration of CD4+ count level, and development of metabolic complications. Furthermore, vitamin D supplementation intervention study provided contradictory results, implying that more research is needed. In general, corroborated findings established protection and potency of supplementation of vitamin D among people with HIV receiving antiretroviral therapy. Therefore, according to this review, vitamin D supplementation may be a potential protective therapy for HIV-infected individuals with prior deficiencies.
REFERENCES (47)
1.
Feldman MB, Alexy ER, Thomas JA, Gambone GF, Irvine MK. The association between food insufficiency and HIV treatment outcomes in a longitudinal analysis of HIV-infected individuals in New York City. J Acquir Immune Defic Syndr 2015; 69: 329-337.
2.
Takarinda KC, Mutasa-Apollo T, Madzima B, Nkomo B, Chigu-mira A, Banda M, et al. Malnutrition status and associated factors among HIV-positive patients enrolled in art clinics in Zimbabwe. BMC Nutr 2017; 3: 15. DOI: https://doi.org/10.1186/s40795....
3.
Silva EFR, Lewi DS, Vedovato GM, Garcia VRS, Tenore SB, Bassichetto KC. Nutritional and clinical status and dietary patterns in individuals living with HIV/AIDS in outpatient care in Sao Paulo, Brazil. Rev Bras Epidemiol 2010; 13: 677-688.
4.
Vizcarra P, Vivancos MJ, Pérez-Elías MJ, Moreno A, Casado JL. Weight gain in people living with HIV switched to dual therapy. AIDS 2020; 34: 155-157.
5.
Sashindran VK, Thakur R. Malnutrition in HIV/AIDS: aetiopathogenesis. In: Nutrition and HIV/AIDS – Implication for Treatment, Prevention and Cure. Dumais N (ed.). IntechOpen, 2020. DOI: 10.5772/intechopen.90477.
6.
Muhangi L, Lule SA, Mpairwe H, Ndibazza J, Kizza M, Nampijja M, et al. Maternal HIV infection and other factors associated with growth outcomes of HIV-uninfected infants in Entebbe, Uganda. Public Health Nutr 2013; 16: 1548-1557.
7.
Kabthymer RH, Nega Techane S, Muche T, Ali Ewune H, Mekonnen Abate S, Feyisso Shaka M. Overweight and obesity among adult HIV infected peoples receiving ART in Ethiopia: a systematic review and meta-analysis. J Prim Care Community Health 2021; 12: 2150132721993647. DOI: 10.1177/2150132721993647.
8.
Beraldo RA, Santos AP, Guimarães MP, Vassimon HS, Paula FJ, Machado DR, et al. Body fat redistribution and changes in lipid and glucose metabolism in people living with HIV/AIDS. Rev Bras Epidemiol 2017; 20: 526-536.
9.
Singhania R, Kotler DP. Lipodystrophy in HIV patients: its challenges and management approaches. HIV AIDS (Auckl) 2011; 3: 135-143.
10.
Raposo MA, Armiliato GN, Guimarães NS, Caram CA, Silveira RD, Tupinambás U. Metabolic disorders and cardiovascular risk in people living with HIV/AIDS without the use of antiretroviral therapy. Rev Soc Bras Med Trop 2017; 50: 598-606.
11.
Mujawar Z, Rose H, Morrow MP, Pushkarsky T, Dubrovsky L, Mukhamedova N, et al. Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. PLoS Biol 2006; 4: e365. doi: 10.1371/journal.pbio.0040365.
12.
Lake JE, Hoffman RM, Tseng CH, Wilhalme HM, Adams JS, Currier JS. Success of standard dose vitamin D supplementation in treated human immunodeficiency virus infection. Open Forum Infect Dis 2015; 2: ofv068. DOI: 10.1093/ofid/ofv068.
13.
Boccara F, Lang S, Meuleman C, Ederhy S, Mary-Krause M, Costagliola D, et al. HIV and coronary heart disease: time for a better understanding. J Am Coll Cardiol 2013; 61: 511-523.
14.
Valdivia A, Ly J, Gonzalez L, Hussain P, Saing T, Islamoglu H, et al. Restoring cytokine balance in HIV-positive individuals with low CD4 T cell counts. AIDS Res Hum Retroviruses 2017; 33: 905-918.
15.
Cavenaghi FM, Bataglion CA, Paula PC, Motta AC, Komesu MC. Protease inhibitor and metabolic alteration. Int J Morphol 2012; 30: 439-444.
16.
Hejazi N, Rajikan R, Kwok Choong CL, Sahar S. Metabolic abnormalities in adult HIV infected population on antiretroviral medication in Malaysia: a cross-sectional survey. BMC Public Health 2013; 13: 758. DOI: 10.1186/1471-2458-13-758.
17.
Santiprabhob J, Tanchaweng S, Maturapat S, Maleesatharn A, Lermankul W, Sricharoenchai S, et al. Metabolic disorders in HIV-infected adolescents receiving protease inhibitors. Biomed Res Int 2017; 2017: 7481597. DOI: 10.1155/2017/7481597.
18.
Awodele O, Olayemi SO, Nwite JA, Adeyemo TA. Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients. J Infect Dev Ctries 2012; 6: 79-85.
19.
Margaritis M. Endothelial dysfunction in HIV infection: experimental and clinical evidence on the role of oxidative stress. Ann Res Hospitals 2019; 3: 7.
20.
Angeles-Agdeppa I, Perlas IA, Capanzana MV. Vitamin D status of Filipino adults: evidence from the 8th National Nutrition Survey 2013. Malaysian Journal of Nutrition 2018; 24: 395-406.
21.
Wimalawansa SJ. Vitamin D deficiency: Effects on oxidative stress, epigenetics, gene regulation, and aging. Biology 2019; 8: 30. DOI: 10.3390/biology8020030.
22.
Sharma B. Oxidative stress in HIV patients receiving antiretroviral therapy. Curr HIV Res 2014; 12: 13-21.
23.
Hoffman RM, Lake JE, Wilhalme HM, Tseng CH, Currier JS. Vitamin D levels and markers of inflammation and metabolism in HIV-infected individuals on suppressive antiretroviral therapy. AIDS Res Hum Retroviruses 2016; 32: 247-254.
24.
Suresh DR, Annam V, Pratibha K, Prasad BVM. Total antioxidant capacity – a novel early bio-chemical marker of oxidative stress in HIV infected individuals. J Biomed Sci 2009; 16: 61. DOI: 10.1186/1423-0127-16-61.
25.
Mebrat Y, Amogne W, Mekasha A, Gleason RL, Seifu D. Lipid peroxidation and altered antioxidant profiles with pediatric HIV infection and antiretroviral therapy in Addis Ababa, Ethiopia. Journal of Tropical Pediatrics 2016; 63: 196-202.
26.
Aziz M, Livak B, Burke-Miller J, French AL, Glesby MJ, Sharma A, et al. Vitamin D insufficiency may impair CD4 recovery among women’s interagency HIV study participants with advanced disease on HAART. AIDS 2013; 27: 573-578.
27.
Deshwal R, Arora S, High prevalence of vitamin D deficiency in HIV infected on antiretrviral therapy in a cohort of Indian patients. Journal of the Association of Physicians of India 2019; 67: 42-45.
28.
Allavena C, Delpierre C, Cuzin L, Rey D, Viget N, Bernard J, et al. High frequency of vitamin D deficiency in HIV-infected patients: effects of HIV-related factors and antiretroviral drugs. J Antimicrob Chemother 2012; 67: 2222-2230.
29.
Sluyter JD, Manson JE, Scragg R. Vitamin D and clinical cancer outcomes: a review of meta-analyses. JBMR Plus 2020; 5: e10420. DOI: 10.1002/jbm4.10420.
30.
Antony S, Oneyka MC, Ciriza F. Vitamin deficiency and HIV infection, a retrospective study looking at possible causal factors in the Hispanic population with HIV. Int J Infect 2018; 5: e79894. DOI: 10.5812/iji.79894.
31.
Visser ME, Durao S, Sinclair D, Irlam JH, Siegfried N. Micronutrient supplementation in adults with HIV infection. Cochrane Database Syst Rev 2017; 5: CD003650. DOI: 10.1002/14651858.CD003650.pub4.
32.
Irlam JH, Siegfried N, Visser ME, Rollins NC. Micronutrient supplementation for children with HIV infection. Cochrane Database Syst Rev 2013; 2013: CD010666. DOI: 10.1002/14651858.CD010666.
33.
Coelho L, Cardoso SW, Luz PM, Hoffman RM, Mendonça L, Veloso VG, et al. Vitamin D3 supplementation in HIV infection: Effectiveness and associations with antiretroviral therapy. Nutr J 2015; 14: 81. DOI: 10.1186/s12937-015-0072-6.
34.
Kakalia S, Sochett EB, Stephens D, Assor E, Read SE, Bitnun A. Vitamin D supplementation and CD4 count in children infected with human immunodeficiency virus. J Pediatr 2011; 159: 951-957.
35.
Steenhoff AP, Schall JI, Samuel J, Seme B, Marape M, Ratshaa B, et al. Vitamin D₃ supplementation in Batswana children and adults with HIV: a pilot double blind randomized controlled trial. PLoS One 2015; 10: e0117123. DOI: 10.1371/journal.pone.0117123.
36.
Stallings VA, Schall JI, Hediger ML, Zemel BS, Tuluc F, Dougher-ty KA, et al. High-dose vitamin D3 supplementation in children and young adults with HIV. Pediatr Infect Dis J 2015; 34: e32-e40. DOI: 10.1097/INF.0000000000000483.
37.
Shepherd L, Souberbielle JC, Bastard JP, Fellahi S, Capeau J, Reekie J, et al. Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. J Infect Dis 2014; 210: 234-243.
38.
Falasca K, Ucciferri C, Di Nicola M, Vignale F, Di Biase J, Vecchiet J. Different strategies of 25OH vitamin D supplementation in HIV-positive subjects. Int J STD AIDS 2014; 25: 785-792.
39.
Roozbeh F, Ghajar M. Effect of vitamin D supplementation with anti-viral therapy on CD4 levels in HIV-infected patients: systematic review and meta-analysis. Int J Med Investig 2018; 7: 1-10.
40.
Okechukwu IB. Oxidative stress, redox regulation and elite controllers of HIV infection: towards a functional cure. In: Trends in Basic and Therapeutic Options in HIV Infection – Towards a Functional Cure. Okechukwu IB (ed.). Intech Open 2015; 7: 173-207. DOI: 10.5772/60806.
41.
Margolis AM, Heverling H, Pham PA, Stolbach A. A review of the toxicity of HIV medications. J Med Toxicol 2013; 10: 26-39.
42.
Wimalawansa SJ. Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation, and aging. Biology (Basel) 2019; 8: 30. DOI: 10.3390/biology8020030.
43.
Jiménez-Sousa MÁ, Martínez I, Medrano LM, Fernández-Rodríguez A, Resino S. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol 2018; 9: 458. DOI: 10.3389/fimmu.2018.00458.
44.
Theodorou M, Sersté T, Van Gossum M, Dewit S. Factors associated with vitamin D deficiency in a population of 2044 HIV-infected patients. Clin Nutr 2014; 33: 274-279.
45.
Poiana C, Capatina C, Cercel AS, Sandulescu O, Streinu Cercel A. Hypovitaminosis D in HIV-infected patients. Acta Endocrinol (Buchar) 2019; 5: 102-106.
46.
Ezeamama AE, Guwatudde D, Wang M, Bagenda D, Kyeyune R, Sudfeld C, Manabe YC, Fawzi WW. Vitamin-D deficiency impairs CD4+T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: a longitudinal study. Clin Nutr 2016; 35: 1110-1117.
47.
Kanwal W, Rehman A. High prevalence of vitamin D deficiency in HIV-infected individuals in comparison with the general population across Punjab province, Pakistan. Saudi J Biol Sci 2023; 30: 103484. DOI: 10.1016/j.sjbs.2022.103484.
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