Kaposi’s sarcoma is an uncommon malignant vascular neoplasm linked to human herpesvirus type 8 (HHV-8); it is a tumor characterized by proliferation of HHV-8-associated spindle cells and abnormal neo-vasculature. Although Kaposi’s sarcoma has been described in immunocompetent subjects, strong inter-relationships with host immunity lead to higher prevalence in people living with human immunodeficiency virus (HIV). HIV infection has been historically associated with malignancies, such as Kaposi’s sarcoma. Usually, it causes abnormalities that develop in tissues below the skin surface anywhere on the body or in mucous membranes of the mouth. Some authors have observed that malignancy is becoming a major cause of death among HIV-infected individuals in industrialized nations. In non-industrialized countries, profound weaknesses have been demonstrated in the diagnostic muscle of infectious diseases in general, with viral diseases being no exception. Treatment may consist of surgery, chemotherapy, or a combination of these treatment techniques. Combination of two or more of these treatment methods has become an important approach for increasing patient’s chance of cure and prolonging survival. There are four clinical presentations: classic, endemic, associated with iatrogenic immunosuppression, and associated with acquired immunodeficiency syndrome. This article presented a clinical case of an HIV-seropositive patient affected by disseminated angiomatous lesions, diagnosis, therapeutic options, and evolution.