Introduction:
The association of human immunodeficiency virus (HIV) infection with the development of autoimmune disorders or systemic diseases is intriguing. Here, we describe a case of HIV-positive individual, who developed a bullous pemphigoid with several autoimmune disorders.

Case description:
A 58 year-old man was admitted to infectious diseases department in June, 2020 due to fever and blistering skin lesions. After several investigations, diagnosis of HIV infection and nodal tuberculosis as opportunistic infection, associated with a bullous pemphigoid was made. Topi­cal corticosteroids and anti-tuberculosis therapy began in June, 2020. Antiretroviral therapy started in August, 2020, with a good virological response. Four months later, in December 2020, the patient developed polyarthralgia and bilateral episcleritis. Testing for anti-nuclear antibodies and rheumatoid factors were positive. Autoimmune diseases were suspected, and the patient was treated with oral corticosteroids for two months with favorable outcome. However, in July, 2021, after the end of corticotherapy, clinical signs reappeared and the patient died of an acute kidney failure.

Conclusions:
Pathophysiology of autoimmune diseases in HIV population remains uncertain. There are several issues that need further studies regarding therapy, especially when systemic corticosteroids and immunosuppressive drugs are under consideration.