CASE REPORT
Genetic diagnosis of seronegative (HIV−) partner of female patient with AIDS in the context of HIV transmission
Online publication date: 2016-06-27
HIV & AIDS Review 2016;15(2):97-100
KEYWORDS
ABSTRACT
Aim
Complex genetic diagnosis of seronegative (HIV−) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review.
Background
HIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high.
Objective
We focused on the genetic diagnosis of serodiscordant couple. We determined the presence of CCR5-Δ32, CCR2-64I, HLA-B, killer cell immunoglobulin-like receptor (KIR) and their ligand genes and human endogenous retroviruses K113 and K115.
Methods
Genotyping was performed using PCR methods.
Results
Analysis of partner's genotype revealed the presence of CCR5-Δ32/Δ32 and KIR genes encoding activating receptors (KIR2DS1, 2DS5, 3DS1), features associated with reduced risk of HIV transmission. Similarities in patient's and her partner's HLA (HLA-B*51) and similar inhibitory KIR repertoire and their ligands (KIR2DL1+HLA-C2, KIR2DL3+HLA-C1, KIR3DL1+HLA-B Bw4-80Ile) could favor the transmission of the virus.
Conclusion
Genetic diagnosis is not routinely recommended, observation of exposed and uninfected individuals would allow to implement new knowledge into more effective care.
Complex genetic diagnosis of seronegative (HIV−) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review.
Background
HIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high.
Objective
We focused on the genetic diagnosis of serodiscordant couple. We determined the presence of CCR5-Δ32, CCR2-64I, HLA-B, killer cell immunoglobulin-like receptor (KIR) and their ligand genes and human endogenous retroviruses K113 and K115.
Methods
Genotyping was performed using PCR methods.
Results
Analysis of partner's genotype revealed the presence of CCR5-Δ32/Δ32 and KIR genes encoding activating receptors (KIR2DS1, 2DS5, 3DS1), features associated with reduced risk of HIV transmission. Similarities in patient's and her partner's HLA (HLA-B*51) and similar inhibitory KIR repertoire and their ligands (KIR2DL1+HLA-C2, KIR2DL3+HLA-C1, KIR3DL1+HLA-B Bw4-80Ile) could favor the transmission of the virus.
Conclusion
Genetic diagnosis is not routinely recommended, observation of exposed and uninfected individuals would allow to implement new knowledge into more effective care.
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| eISSN: | 1732-2707 |
| ISSN: | 1730-1270 |
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